As the son of broadcast journalist Nick Clooney and the nephew of chanteuse Rosemary Clooney, George Clooney entered the world with show business coursing through his veins. Born May 6, 1961 in Lexington, Kentucky, the future E.R. headliner appeared at the tender age of five on his father's Cincinnati talk program, The Nick Clooney Show. In his youth, Clooney honed a sharp interest in sports - particularly baseball - but by adulthood, Clooney launched himself as an onscreen presence, seemingly without effort. Beginning with a string of television commercials, then signed with Warner Brothers Entertainment as a supporting player. By the time Clooney had paid his dues, he'd appeared in single episodes of The Golden Girls, Riptide, Crazy Like a Fox, Street Hawk and Hunter.
After regular gigs on TV shows like The Facts of Life, Roseanne, and Sisters, Clooney scored a role on the NBC medical drama E.R., which proved his breakthrough to superstardom. When that program shot up to #1 in prime time ratings, Clooney carried it (much more, in fact, than a first-billed Anthony Edwards) - his inborn appeal to women and his onscreen grace and charm massive contributing factors. This appeal increased as his character - initially something of a callous womanizer - matured with the show, eventually evolving into a kind and thoroughly decent, if somewhat hotheaded, human being.